Prone positioning and anterior chest wall loading to homogenize ventilation distribution in patients with acute respiratory distress syndrome and veno-venous extracorporeal membrane oxygenation

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033518

Enrollment

Registered

2024-01-29

Start date

2024-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: To evaluate the influence of prone positioning and anterior chest wall loading under ultraprotective ventilation with different tidal volumes on pulmonary ventilation distribution, lung mecha

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 < 100 mmHg Treatment with veno-venous extracorporeal membrane oxygenation

Exclusion criteria

Exclusion criteria: Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Design outcomes

Secondary

Measure	Time frame
This study evaluates the effects of prone positioning and anterior chest wall loading on the mechanics of the partitioned respiratory system (lung and chest wall), pulmonary ventilation and perfusion distribution, hemodynamics, and gas exchange.	—

Primary

Measure	Time frame
Transpulmonary Driving Pressure during ultraprotective ventilation The measurements are conducted and compared in the supine position, prone position, and during anterior chest wall loading.	—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätsmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026