C71
Conditions
Interventions
Group 1: Repetitive navigated transcranial magnetic stimulation (rnTMS) at 1 Hz for 15 minutes per session (900 pulses) for 7 days week-daily. RnTMS is applied to the contralesional primary motor cort
Sponsors
Charité - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients after resection of a supratentorial brain tumor - Deterioration of motor status immediately postoperatively compared to preoperative status - Age = 18 years - Patients whose physical and mental condition allows them to give full and comprehensive informed consent - Written declaration of consent
Exclusion criteria
Exclusion criteria: - Patients with contraindications for MRI imaging - Patients with contraindications for a TMS examination - >1 generalized seizure per week - Pregnancy - Age < 18 years - Lack of consent to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Responsiveness as the proportion of treatment successes of patients based on the difference ? of the BMRC value of the treated extremity one month postoperatively compared to the baseline BMRC value before the start of rTMS therapy (success if ? = 1). | — |
Secondary
| Measure | Time frame |
|---|---|
| - National Institutes of Health Stroke Scale (NIHSS) - Finger or toe tapping score depending on the affected extremity - Karnofsky Performance Status Scale (KPS) - Quality of life (EORTC QLQ BN20) - Characteristics of the tumor (location, volume, histology) - Characteristics of the operation (anesthesia, extent of resection, resection of motor eloquent areas, presence of ischemia) - TMS parameters (resting motor threshold, measurability of MEPs) | — |
Countries
Germany
Contacts
Public ContactThomas Picht
Charité - Universitätsmedizin Berlin
Outcome results
None listed