Lung failure (ARDS)
Conditions
Interventions
Group 1: Intervention group:
Cooling (0.5°C per hour) followed by maintaining core body temperature at 34°C using the "Arctic Sun."
Intervention period:
Maximum of 5 days from reaching the target tem
Sponsors
Charité - Universitätsmedizin Berlin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Adults of any gender - ARDS according to the Berlin Definition (of any origin) - Intensive care therapy with invasive mechanical ventilation - VV-ECMO with blood flow >4.5 lpm - Deep analgosedation (RASS -5)
Exclusion criteria
Exclusion criteria: - Severe intra-abdominal, thoracic, gastrointestinal, and/or intracerebral - Bleedings - Severe thrombocytopenia ( 8) - Uncontrolled shock of any origin (Norepinephrine > 0.4 µg/kg/min) - Bradycardia <55 bpm - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood flow within the intervention period | — |
Secondary
| Measure | Time frame |
|---|---|
| ECMO blood flow after rewarming, time on ECMO, revolutions per minute of the ECMO, internal pressures of the ECMO, ECMO gas flow, duration of ventilation/ventilation parameters, proportion of primary extubation versus tracheotomy, extrapulmonary organ dysfunction, radiological progression of infiltrates, thrombotic and bleeding-related complications, transfusion requirements, hemostatic support, discharge from the Intensive Care Unit (ICU), mortality (30 days), hemolysis, coagulation profile, inflammatory markers, liver/kidney function, catecholamine requirements. | — |
Countries
Germany
Contacts
Public ContactJulius Kunz
Charité - Universitätmedizin Berlin
Outcome results
None listed