Prediction of neurological outcome after out of hospital cardiac arrest - a prospective observational study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033447

Enrollment

300

Registered

2024-01-19

Start date

2023-08-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I46.0

Interventions

Group 1: Observation group: All persons >=18 years of age are included in this study. Additional parameters for neurological prognosis, which are currently not yet routinely recorded, are examined as

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients: - Out-of-hospital cardiac arrest of any cause with resuscitation efforts by emergency medical services - Consent by legal representatives and/or patient after regaining consciousness Healthy subjects: - Capacity to consent - Consent by the subject - Age =18 years

Exclusion criteria

Exclusion criteria: Patients: - Prisoners - Living will prohibit resuscitation and intensive care measures Healthy test subjects: - Condition after circulatory arrest - Neurological deficit, defined as a previous stroke, cerebral hemorrhage, or known epilepsy - Chronic renal insufficiency, regardless of the stage - Illness from the psychiatric spectrum

Design outcomes

Primary

Measure	Time frame
Do the whole blood transcriptome, organ-specific damage as determined by methylation-specific PCR, and peripheral immune cell composition at the time of cardiac arrest, 24 and 72 hours after ROSC, and at 30 days differ between subjects with good neurologic survival (CPC 1-2) and subjects with poor neurologic survival (CPC 3-4) at day 30 after OHCA?	—

Secondary

Measure	Time frame
1) Do the whole blood transcriptome, organ-specific damage as determined by methylation-specific PCR, and peripheral immune cell composition at the time of cardiac arrest and at 24 hours differ between individuals with good neurologic survival (CPC 1-2) at day 30 after OHCA and individuals who die within 24 hours of hospital admission? 2) How does the whole blood transcriptome change over the course of treatment? 3) Are there differences in organ-specific damage, as determined by methylation-specific PCR, in individuals with OHCA based on survival and neurologic status at day 30? 4) Does the composition of peripheral immune cells correlate with the whole blood transcriptome? 5) Can patients with good/poor neurological survival be identified at an early stage using these parameters? 6) 30-day survival and assessment of health status at this point in time 7) How accurate is a prognosis score that is developed on the basis of these parameters? 8) Do the whole blood transcriptome, organ-specific damage and peripheral immune cell composition differ between subjects with circulatory arrest at any of the four time points (resuscitation, 24h, 72h after ROSC and after 30 days) with the results of healthy subjects?	—

Measure

Time frame

1) Do the whole blood transcriptome, organ-specific damage as determined by methylation-specific PCR, and peripheral immune cell composition at the time of cardiac arrest and at 24 hours differ between individuals with good neurologic survival (CPC 1-2) at day 30 after OHCA and individuals who die within 24 hours of hospital admission? 2) How does the whole blood transcriptome change over the course of treatment? 3) Are there differences in organ-specific damage, as determined by methylation-specific PCR, in individuals with OHCA based on survival and neurologic status at day 30? 4) Does the composition of peripheral immune cells correlate with the whole blood transcriptome? 5) Can patients with good/poor neurological survival be identified at an early stage using these parameters? 6) 30-day survival and assessment of health status at this point in time 7) How accurate is a prognosis score that is developed on the basis of these parameters? 8) Do the whole blood transcriptome, organ-specific damage and peripheral immune cell composition differ between subjects with circulatory arrest at any of the four time points (resuscitation, 24h, 72h after ROSC and after 30 days) with the results of healthy subjects?

—

Countries

Germany

Contacts

Public ContactStephan Katzenschlager

Universitätsklinikum Heidelberg, Klinik für Anästhesiologie

Stephan.Katzenschlager@med.uni-heidelberg.de+4962215639683

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026