Interaction between ventilation strategy, lung volume, and hemodynamics in patients with acute respiratory distress syndrome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033400

Enrollment

Registered

2024-01-22

Start date

2024-01-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: To investigate the influence of individualized settings of tidal volume and positive end-expiratory pressure (PEEP) on pulmonary ventilation distribution, lung mechanics and volume, gas excha

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Moderate to severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 =150 mmHg

Exclusion criteria

Exclusion criteria: Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Design outcomes

Primary

Measure	Time frame
Lung total elastic power and its components (elastic static and elastic dynamic power) normalized to end-expiratory lung volume. The measurements are performed and compared with individualized tidal volume and PEEP settings.	—

Secondary

Measure	Time frame
Secondary endpoints are the effects of individualized settings of tidal volume and PEEP on the partitioned respiratory system mechanics (lung and chest wall), end-expiratory lung volume, pulmonary ventilation and perfusion distribution, hemodynamics and gas exchange.	—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätsmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026