Prone positioning and Anterior chEsT wall loading to Homogenize vEntilation distRibution In aCute respiratory distress syndrome patients

Prone positioning and Anterior chEsT wall loading to Homogenize vEntilation distRibution In aCute respiratory distress syndrome patients - AETHERIC

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033339

Enrollment

Registered

2024-01-22

Start date

2024-01-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: Evaluation of the influence of prone positioning over the course of the 16-hour treatment period on pulmonary ventilation distribution, lung mechanics and volume, gas exchange, and hemodynami

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Moderate to severe acute respiratory distress syndrome (ARDS) with PaO2/FiO2 =150 mmHg

Exclusion criteria

Exclusion criteria: Age < 18 years, contraindications to prone positioning, pregnancy, presence of a cardiac pacemaker and/or implanted defibrillator, and life expectancy < 24 hours.

Design outcomes

Primary

Measure	Time frame
Lung total elastic power and its components (elastic static and elastic dynamic power) normalized to end-expiratory lung volume. Measurements will be performed in supine positioning, in prone positioning, following 16 hours of prone positioning and 1 hour after the transfer to supine positioning.	—

Secondary

Measure	Time frame
Secondary endpoints are the effects of prone positioning and anterior chest wall loading on partitioned respiratory system mechanics (lung and chest wall), end-expiratory lung volume, pulmonary ventilation and perfusion distribution, hemodynamics, gas-exchange, and serum biomarkers.	—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026