Small fiber neuropathy with neuropathic pain
Conditions
Interventions
Group 1: Repetitive magnetic stimulation of the M1 area on the left
Group 2: Repetitive magnetic stimulation of the DLPFC area on the left
Sponsors
Uniklinik der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clinically confirmed small fiber neuropathy 2. Neuropathic pain as the lead symptom of SFN 3. No underlying acquired origin of nerve damage 4. Written informed consent prior to project participation 5. The subject is willing and able to follow the procedures outlined in the project plan
Exclusion criteria
Exclusion criteria: 1. Minority <18 years of age 2. Pregnancy and breastfeeding 3. Known epilepsy or epileptic seizure in the past 4. Serious brain disease (e.g. hydrocephalus, brain tumor) or serious head injury (traumatic brain injury) in the past or present 5. Other serious or unstable illness (e.g. asthma, coronary artery disease) that requires, for example, the wearing of electrical devices (e.g. pacemaker, drug pump) or metal parts (e.g. screws after bone fracture) in or on the body 6. Large tattoos that might interact with the magnetic field 7. Persons who are placed in an institution by court or official order 8. People who are unwilling or unable to understand and follow the instructions of the study 9. People who are incapable of giving consent and/or are unable to understand the nature, significance, and scope of the research project and to give their consent in writing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain reduction (NRS) by 30% compared to baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| - Correlation of pain scores with depression markers - Comparison of two different stimulation localizations - Stratification of patients who may or may not respond to rTMS based on phenotype markers | — |
Countries
Germany
Contacts
Public ContactMaike Dohrn
Uniklinik der RWTH Aachen
Outcome results
None listed