Collaborative project "Personalized Digital Lung Twin For The Treatment Of Acute Lung Failure"

Collaborative project "Personalized Digital Lung Twin For The Treatment Of Acute Lung Failure" - UBIC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033324

Enrollment

100

Registered

2024-02-26

Start date

2024-04-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80

Interventions

Group 1: The aim of this observational study is to investigate which model parameters of this digital lung twin (e.g. regional stress and strain) correlate with the clinical treatment outcome (e.g. 28

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Ventilated patients with acute hypoxemic respiratory failure, defined as PaO2/FiO2 ratio = 300 mmHg during invasive or non-invasive ventilation with PEEP >= 5 mbar. - Presence of a CT thorax or X-ray thorax for clinical indication, not older than 48 h - Written consent by patient or legal representative

Exclusion criteria

Exclusion criteria: - Age under 18 years - Pregnancy

Design outcomes

Primary

Measure	Time frame
28-day mortality	—

Secondary

Measure	Time frame
- Ventilator-free days - 90-day mortality - Influence of positioning maneuvers (e.g. clinically indicated prone positioning for severe ARDS) on ventilation and gas exchange Effects of innovative ventilation concepts such as variable variable pressure support ventilation (noisyPSV) and diaphragmatic EMG-triggered pressure support ventilation (Neurally Adjusted Ventilatory Assist-NAVA) on patient-ventilator synchrony, respiratory mechanics and gas exchange - Effects of the reduction in ventilation invasiveness through the use of extracorporeal membrane oxygenation (ECMO) on regional and global mechanical stress (stress/strain) - Identification of ventilator-associated risk factors for the development of delirium - Effect of clinically indicated changes in ventilator settings on respiratory mechanics, regional and global mechanical stress and hemodynamic parameters - Spatial ventilation distribution within the lung, regional recruitment, derecruitment and overdistension	—

Measure

Time frame

- Ventilator-free days - 90-day mortality - Influence of positioning maneuvers (e.g. clinically indicated prone positioning for severe ARDS) on ventilation and gas exchange Effects of innovative ventilation concepts such as variable variable pressure support ventilation (noisyPSV) and diaphragmatic EMG-triggered pressure support ventilation (Neurally Adjusted Ventilatory Assist-NAVA) on patient-ventilator synchrony, respiratory mechanics and gas exchange - Effects of the reduction in ventilation invasiveness through the use of extracorporeal membrane oxygenation (ECMO) on regional and global mechanical stress (stress/strain) - Identification of ventilator-associated risk factors for the development of delirium - Effect of clinically indicated changes in ventilator settings on respiratory mechanics, regional and global mechanical stress and hemodynamic parameters - Spatial ventilation distribution within the lung, regional recruitment, derecruitment and overdistension

—

Countries

Germany

Contacts

Public ContactTobias Becher

Universitätsklinikum Schleswig-Holstein, Campus Kiel

Tobias.Becher@uksh.de+4943150020980

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026