Mechanical ventilation
Conditions
Interventions
Group 1: Medical data will be assessed in intervals in patients undergoing mechanical ventilation on intensive care units.
Sponsors
Universitätsklinikum Carl Gustav Carus an der TU Dresden, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients admitted to intensive care unit within enrolment window; initiation of high-flow nasal oxygen (HFNO, =30 l/min) or NIV/CPAP with at least 5 cmH2O expiratory pressure or invasive mechanical ventilation within enrolment window
Exclusion criteria
Exclusion criteria: Age <18 years; ventilated patients transferred from another hospital under ongoing invasive or non-invasive ventilation (incl. high flow oxygen therapy (=30l/min)); (Inability to obtain written informed consent for participation and/or data usage, if locally mandated)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients ventilated invasively within lung-protective limits, defined as tidal volume of =8 ml/kg predicted body weight and positive end-expiratory pressure of =5 cmH2O (both must be met) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Demographics/Cohort characteristics (incl. medical history as well as reasons for ICU admission and mechanical ventilation); • Disease severity scores, Lung injury prediction score (LIPS), sedation scores; • Ventilator modes and settings; • Vital signs, incl. respiratory variables and haemodynamics; • Proportion of patients at risk for ARDS (LIPS =4 points); • Rate of progression to ARDS; • Incidence of Non-intubated ARDS; • Incidence of missed ARDS diagnosis; • Utilization of adjunctive therapies, i.e. neuro-muscular blockade, prone positioning, extra-corporeal techniques, inhalative NO, etc.; • Utilization of adjunctive diagnostics, i.e. daily chest X-ray, lung ultrasound, electrical impedance tomography, and oesophageal pressure measurement; • Rate of extra-/ pulmonary complications; • ICU Mortality rate, hospital mortality rate, mortality at day 28 and 90; • Length of ICU stay; • Duration of invasive mechanical ventilation; • Ventilator-free and ECMO-free days at day 28 and 90; • ICU- and hospital-free days at day 28 and 90; • Site-level organisational, staffing, and resource information will be collected via a one-time online survey. | — |
Countries
Germany
Contacts
Public ContactMartin Scharffenberg
Universitätsklinikum Carl Gustav Carus an der TU Dresden, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie
Outcome results
None listed