Perioperative endothelial function measurement
Conditions
Interventions
Group 1: Group 1 (n=40)
Age 18-35 years
Surgical intervention with low risk
No risk factors for endothelial dysfunction
Group 2: Group 2 (n=10)
Age >=45 years
Surgical procedure with high risk and dur
Sponsors
Universitätsklinikum Göttingen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Group 1 (n=40) Age 18-35 years Surgical intervention with low risk No risk factors for endothelial dysfunction - Group 2 (n=10) Age >=45 years Surgical procedure with high risk and duration >2 hours At least 2 risk factors for endothelial dysfunction
Exclusion criteria
Exclusion criteria: Age <18 years. ? Pregnancy and breastfeeding ? Septic patients ? Patients with calcium antagonists or nitrate medication ? Patients with long-term corticosteroid therapy ? Emergency interventions ? Patients with Raynaud's syndrome and/or peripheral arterial disease and/or vasculitis ? Patients undergoing surgical procedures with tourniquets
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absence or reduced increase in plethysmographic measured pulse wave amplitude after occlusion test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Major adverse cardiovascular events (nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death [30]), abnormalities of laboratory parameter with indications of endothelial dysfunction, development of laboratory parameter for systemic inflammation. | — |
Countries
Germany
Contacts
Public ContactReiner Wäschle
Universitätsmedizin Göttingen
Outcome results
None listed