C61
Conditions
Interventions
Group 1: Classic image-guided radiation therapy (Image-Guided Radiation Therapy, IGRT) with additional online adaptive radiation therapy (ART)
Dosimetric and clinical evaluation of the effectiveness
Sponsors
Klinik und Poliklinik für Strahlentherapie des Universitätsklinikums Essen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with histologically confirmed, localized or locally advanced prostate cancer who are to receive postoperative radiotherapy of the prostate after an interdisciplinary tumor board decision and specialist assessment
Exclusion criteria
Exclusion criteria: Patients who cannot lie for longer than 15 minutes. Patients who are to receive radiotherapy of the lymphatic drainage are not included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is to test the hypothesis, whether with standard PTV safety margins, ART provides dosimetric advantages over IGRT in more than 10% of patients with postoperative radiotherapy (H1). | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is to evaluate, whether cases with an EUD<95% can be identified with the accumulated dose distribution early during the treatment series based on the EUD values for the individual fractions. Furthermore, the extent to which the planning safety margins around the CTV can be reduced to compensate for movements and deformations with online-adaptive radiotherapy (ART) compared to IGRT will be examined. | — |
Countries
Germany
Contacts
Public ContactNika Guberina
Klinik und Poliklinik
Outcome results
None listed