Burn patients in need of ventilation
Conditions
Interventions
Group 1: Flow-controlled ventilation (FCV) with an individualised positive end-expiratory pressure and an individualised driving pressure, resulting in a liberal tidal volume
Group 2: Controlled Bipha
Sponsors
Klinik für Anästhesiologie, Intensiv- und Schmerzmedizin; BG Universitätsklinikum Bergmannsheil Bochum gGmbH
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - in already ventilated patients: invasive ventilation for = 24 hours before admission to the Burn Centre - in not ventilated patients: indication for tracheal intubation and controlled ventilation within 48 hours of admission to the Burn Centre - estimated (further) duration of ventilation = 24 hours - start of intervention = 48 hours after admission to the Burn Centre - a central venous catheter and an arterial line for the intensive care treatment - signed informed consent by the patient or a legal presentative, by a representative of the patients will in incompetent patients or by a study-independent physician in charge in incompetent patients without a respresentative of the patients will
Exclusion criteria
Exclusion criteria: - participation in another interventional trial - invasive ventilation for > 24 hours before admission to the Burn Centre - start of the intervention > 48 hours after admission to the Burn Centre - estimated (further) duration of ventilation < 24 hours - no informed consent by the patient, by a legal representative, by a representative of the patients will in incompetent patients or by a study-independent physician in charge in incompetent patients without a respresentative of the patients will
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Computed mechanical power in joules per minute (J/min) during up to 70 hours of controlled ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Main study: - oxygenation indices during controlled ventilation - arterial partial pressures of carbon dioxide (PaCO2) during controlled ventilation - ventilation parameters during controlled ventilation - incidences of pulmonary complications up to 10 days after starting the intervention - incidences of extra-pulmonary complications up to 10 days after starting the intervention - duration of ventilation - intensive care unit and total inpatient length of stay - different intensive care scores (including APACHE and SAPS) up to 10 days after starting the intervention - mortality 30 days, 90 days and half a year after starting the intervention Ancillary studies: - parameters of indirect calorimetry during controlled ventilation - parameters of advanced haemodynamic monitoring (including PiCCO-Technology and Acumen IQ Sensor) - characterization of the (acute) lung and burn inhalational injury regarding pulmonary and systemic biomarkers | — |
Countries
Germany
Contacts
Public ContactSimon Becker
Klinik für Anästhesiologie, Intensiv- und Schmerzmedizin; BG Universitätsklinikum Bergmannsheil Bochum gGmbH
Outcome results
None listed