K75.8 K76.0
Conditions
Interventions
Group 1: Single-arm study: Patients with liver fat metabolism disorders are examined by means of cranial MRI and the image data are analysed using machine learning and artificial intelligence methods
Sponsors
Institut für diagnostische und interventionelle Radiologie, Universitätsklinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Outpatient treatment at the local Lipid Metabolism Clinic of the Department of Gastroenterology, Hepatology, and Infectious Diseases - Internally diagnosed fatty liver disease - Age range 40-70 years, regardless of gender - BMI < 35
Exclusion criteria
Exclusion criteria: - Non-compliance with inclusion criteria - Withdrawal of study consent - MRI contraindications (e.g., metal implants, claustrophobia) - Pregnancy and lactation - Lack of consent for communication of incidental MRI findings - Associated diseases with the fatty liver having a significantly high impact on neurodegeneration: - Pathological alcohol consumption (moderate alcohol consumption is tolerated) - Liver cirrhosis - Known malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extent of accelerated brain ageing in patients with chronic hepatic lipid metabolism disorders, measured by non-contrast MRI, at the time of a clinical outpatient follow-up, independent of the date of initial diagnosis. | — |
Countries
Germany
Contacts
Public ContactVivien Lorena Ivan
Institut für diagnostische und interventionelle Radiologie, Universitätsklinikum Düsseldorf
Outcome results
None listed