OPS 8-017Enteral nutrition
Conditions
Interventions
Group 1: Interventional group
12 hours of enteral feeding (as per patients´individual calorimetric requirements measured by indirect calorimetry) followed by a fasting period of 12 hours supported by
Sponsors
Klinik für Anästhesiologie und Operative Intensivmedizin, Uniklinikum Köln
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -written informed consent to participate in this study -admission to ICU -enteral nutrition
Exclusion criteria
Exclusion criteria: -Severe liver dysfunction / liver failure (Child Pugh >7 points / category B) -severe kidney dysfunction (KDIGO stage 3) -Total pancreatectomy / insulin dependent diabetes mellitus (IDDM) -Pregnancy / lactation -Hemoglobin concentration < 80g/l -Severe metabolic disorders / severe autoimmune diseases -Refractory metabolic or respiratory acidosis -Dysfunction of mitochondrial transport of fatty acids -Dysfunction of oxidation of fatty acids -Dysfunction of gluconeogenesis, production and reduction of ketones -Intermittent Porphyria -Severe cardiac arrhythmias / cardiomyopathy -Contraindication against enteral nutrition -Lack of informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Loss of muscle mass (measured on day 3, 7,10 and 14 via Ultrasound of M. rectus femoris of a predefined leg) -Urea / creatinine ratio in the patients´ blood measured on day 3, 7, 10 and 14 | — |
Secondary
| Measure | Time frame |
|---|---|
| -Length of invasive and noninvasive ventilation -Length of ICU and hospital stay -30 day mortality on day 30 -ICU mobility scale on discharge on day 3, 7, 10, 14 -SF-36 (questionnaire) on day of study inclusion and on day 30 | — |
Countries
Germany
Contacts
Public ContactSandra Emily Stoll
Klinik für Anästhesiologie und Operative Intensivmedizin Uniklinikum Köln
Outcome results
None listed