Paired pulse behavior of somatosensory evoked potentials in chronic low back pain and healthy controls - a cross-sectional study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033184

Enrollment

Registered

2024-01-04

Start date

2024-01-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M54.5

Interventions

Group 1: paired pulse behavior of somatosensory evoked potentials of the median nerve is examined once in people with low back pain. Group 2: paired pulse behavior of somatosensory evoked potentials (

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Sufficient cognitive and German language abilities are required to give written informed consent and to follow instructions. Healthy controls are included if they have no current pain, not experienced LBP in the past 2 years and no history of spine surgery. Participants are included if the primary pain is located in the area between the 12th rib and the gluteal folds, persists longer than 3 months and is classified as nonspecific. If radiating pain in the leg is higher than pain in the back, people are excluded from this study even if the painDETECT score is lower than 12.

Exclusion criteria

Exclusion criteria: To exclude people with a neuropathic pain component, people with a painDETECT score higher than 12 are excluded from this study. Moreover participants who are diagnosed with any neurological, psychiatric or other chronic disease, that could impact the function of the somatosensory system (e.g. multiple sclerosis, ADHD, diabetes mellitus, polyneuropathy) are excluded from this study. Moreover people with cardiac pacemakers, metal implants in the arms, hands or trunk and pregnant people are excluded from this study.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure is the paired-pulse behavior of people with CLBP and healthy controls. This is expressed as a ratio (A2/A1) of the peak-to-peak amplitude of the second (A2) and first (A1) cortical N20-P25 median nerve SEP components.	—

Secondary

Measure	Time frame
latencies (N20, P25, N20´, P25´) Central sensitization Inventory German version Brief pain inventory German version WHO Quality of Life BREF German version	—

Countries

Germany

Contacts

Public ContactKatja Ehrenbrusthoff

Hochschule für Gesundheit Bochum

katja.ehrenbrusthoff@hs-gesundheit.de+49 234 77727-626

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026