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(Epi)genetic risk markers, predictors and mechanisms of psychotherapy in acrophobia

(Epi)genetic risk markers, predictors and mechanisms of psychotherapy in acrophobia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00033150
Enrollment
300
Registered
2023-12-12
Start date
2024-01-15
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F40.2

Interventions

Group 1: Intervention group: Receives three psychoeducation sessions, each lasting 100 minutes, and six exposure sessions carried out in virtual reality a 30 min. The intervention spans over six weeks

Sponsors

Universitätsklinikum Freiburg - Klinik für Psychiatrie und Psychotherapie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Caucasian descent (up to the third generation) Proficient in spoken and written German

Exclusion criteria

Exclusion criteria: Current comorbid mental disorders apart from other specific phobias, suicidality (BDI-II item 9>0), severe neurological and/or somatic disorders, illegal drug use (assessed by urine toxicology), pregnancy, impaired 3D sight (as assessed using a stereo depth perception test), general medical contraindications, intake of psychoactive medication, or concomitant psychotherapy. Lifestyle-related habits (smoking, alcohol consumption, caffeine intake, physical activity, diet, BMI) will be recorded; excessive alcohol (more than 14 glasses/week), cigarette (more than 20 cigarettes/day) and caffeine (more than 4 cups/day) consumption will lead to study exclusion.

Design outcomes

Primary

MeasureTime frame
Acrophobia symptoms measured using the Attitudes Towards Heights Questionnaire (ATHQ) and Acrophobia Questionnaire (AQ) before and after the intervention (at T0 and T1 - before and after six weeks after baseline).

Secondary

MeasureTime frame
SUDS - Subjective Units of Discomfort (Measurement Time Points: T0 and T1) CGI - Clinical Global Impression Scale (Severity of Symptoms; Measurement Time Points: T0 and T1) BAI - Beck Anxiety Inventory (Anxiety Symptoms; Measurement Time Points: T0 and T1) AES/DES - Anxiety and Danger Expectancy Scale (Anxiety and Danger Expectancy; Measurement Time Points: T0 and T1) STAI-trait - State-Trait Anxiety Inventory (General Anxiety; Measurement Time Points: T0 and T1) ASI-4 - Anxiety Sensitivity Index 4 (Measurement Time Points: T0 and T1) BPQ - Body Perception Questionnaire (Body Symptoms; Measurement Time Points: T0 and T1) BDI-II - Beck Depression Inventory, Revised Version (Depressive Symptoms; Measurement Time Points: T0 and T1) GSE - General Self-Efficacy Scale (Self-Efficacy; Measurement Time Points: T0 and T1) Moderators: WAI-SR - Working Alliance Inventory – Short Revised (Therapeutic Alliance; Measurement Time Point: T1) IPQ - Igroup Presence Questionnaire (Experience of Presence in Virtual Reality; Measurement Time Point: T1) ITQ - Immersive Tendencies Questionnaire (VR Immersion; Measurement Time Point: T0) SSQ - Simulator Sickness Questionnaire (Simulator Sickness; Measurement Time Point: T0) CTQ - Childhood Trauma Questionnaire (Childhood Trauma; Measurement Time Point: T0) LTE - List of Threatening Experiences (Life Events; Measurement Time Point: T0)

Countries

Germany

Contacts

Public ContactKatharina Domschke

Universitätsklinikum Freiburg - Klinik für Psychiatrie und Psychotherapie

katharina.domschke@uniklinik-freiburg.de+49 761 270 65050

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026