Head- and Neckregion, C00-C14, C40-44, C73-C97 C00-C14 C40-C41 C43-C44 C73-C75 C76-C80 C81-C96 C97
Conditions
Interventions
Group 1: Adaptive radiotherapy (combination IGRT/IMRT/VMAT and ART),
the sessions of an RT series are evaluated and compared onboard with the standard radiotherapy option
(Plan comparison is possible
Sponsors
Klinik für Strahlentherapie, Universitätsklinikum Essen, NCT West
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ECOG performance status 0 or 1
Exclusion criteria
Exclusion criteria: ECOG 2-4, other malignant tumor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose distribution and effective uniform dose in the CTV over the first 7 fractions =95%, or <95%: (The primary endpoint is the accumulated dose distribution in the CTV with the initial treatment plan approved for the series over fractions 1-7 of each patient up to the time of the 10th fraction for each patient in this study and from this the effective uniform dose in the CTV is calculated) | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimal isotropic PTV margin, progression free survival (PFS), overall survival (OS), dose organs at risk (OAR), side effects (CTC AE, LENT-SOMA); quality of life (EORTC), minimal PTV margin, coverage of the CTV with an equivalent uniform dose (EUD) of =95% of the prescribed dose | — |
Countries
Germany
Contacts
Public ContactMaja Guberina
Klinik für Strahlentherapie, Universiätsklinikum Essen, NCT West
Outcome results
None listed