Regenerative potential of the combination of a sodium hypochlorite gel and high molecular weight hyaluronic acid as adjuvants in non-surgical periodontitis therapy – a randomized clinical trial

Regenerative potential of the combination of a sodium hypochlorite gel and high molecular weight hyaluronic acid as adjuvants in non-surgical periodontitis therapy – a randomized clinical trial - CASPAR

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00033136

Enrollment

150

Registered

2024-01-29

Start date

2024-02-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.3

Interventions

Group 1: Non-surgical periodontitis therapy with adjuvant use of a sodium hypochlorite gel and high-molecular hyaluronic acid. The treatment is carried out once on teeth that have residual pockets af

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Stage 3 and 4 periodontitis - Presence of residual pockets (>6mm) after initial AIT - Periodontitis grading B and C - Age greater than or equal to 18 years - Legal capacity - Presence of a written declaration of consent from the subject/patient

Exclusion criteria

Exclusion criteria: - Participation in other interventional trials - Presence of contraindications according to the instructions for use (preparations) - Autoimmune diseases / immunotherapy - Known sensitivity to hyaluronic acid - Strong allergic tendency - Presence of acute inflammatory and infectious processes - Coagulation disorders and anticoagulant therapy - Hormonal diseases - Teeth with indication for extraction due to degree 3 loosening - Teeth with indication for extraction due to endodontic cause (endo-perio lesion) - Periodontitis as a manifestation of systemic diseases - Periodontal defects with furcation involvement where resective exposure is indicated - A history of pregnancy or breastfeeding - Persons who are in a dependent / employment relationship with the sponsor or investigator - Placement in an institution due to a court or official order. - Oral hygiene index (API) > 50%

Design outcomes

Primary

Measure	Time frame
Clinical attachment gain after completion of supportive periodontitis therapy	—

Secondary

Measure	Time frame
Recessions, probing depths, radiographic attachment gain during the study period as part of the clinical routine, bleeding on probing, as well as patient reactions and intolerance to the test products	—

Countries

Germany

Contacts

Public ContactDaniel Diehl

Lehrstuhl für Parodontologie, Universität Witten/Herdecke

daniel.diehl@uni-wh.de+492302926662

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026