F05.0
Conditions
Interventions
Group 1: Patients at ICU with delirium receive stool and blood sampling.
Group 2: Matched patients at ICU without delirium receive stool and blood sampling.
Sponsors
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patient in anesthesiology intensive care unit - Delirium group: positive ICDSC (>=4) in two screenings 8h apart - Control group: no positive ICDSC 72h before and after sampling - Pre-delirium group: no positive ICDSC 72h before sample collection, at least one positive ICDSC within 72h after sample collection
Exclusion criteria
Exclusion criteria: - Invasive ventilation at the time of sample collection - Patients with pre-existing neurocognitive deficits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Proportion (%) of SCFA-producing bacteria in the intestinal microbiome of patients with delirium compared to the control group. 2) SCFA levels in the serum of patients with delirium compared to the control group. 3) Concentration of IL-6 in the serum of patients with delirium compared to the control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Level of alpha diversity of the intestinal microbiome in patients with delirium compared to the control group. 2) Differences in the principal coordinates analysis (PCoA) of the intestinal microbiota between the two groups. 3) Health-related quality of life after 3 and 6 months in patients with delirium compared to the control group. 4) Survival after 3 and 6 months in patients with delirium compared to the control group. | — |
Countries
Germany
Contacts
Public ContactHannah Fahrner
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Freiburg
Outcome results
None listed