Post-COVID syndrome
Conditions
Interventions
Group 1: A total of up to 60 patients with post-COVID syndrome and up to 30 people after infection with SARS-CoV-2 but without post-COVID syndrome will be examined. In addition, MRI data from healthy
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: -Willingness to provide the written informed consent and the ability to give consent. -SARS-CoV-2 infection confirmed by PCR test at least 12 weeks ago and the presence of a clinical neurological post-COVID syndrome (depending on the subgroup, leading symptom complex fatigue/concentration and memory disorder/headache/dizziness or leading symptom complex myopathy/neuropathy). -Inclusion criterion for the control group after SARS-CoV-2 infection without post-COVID syndrome is a SARS-CoV-2 infection at least 12 weeks ago, confirmed by PCR test.
Exclusion criteria
Exclusion criteria: -Contraindications against MRI examinations; if metallic foreign bodies are present, it is checked before the examination whether the materials used are MRI-compatible and the examination can take place without increased risk - Persons with known ischemic infarcts, as well as known hemodynamically relevant extra- and intracranial and vascular diseases - Persons with known neurological or psychiatric illnesses prior to infection with SARS-CoV-2 - Persons with illnesses that prevent them from lying quietly in the examination device for 60 minutes (e.g. pain, claustrophobia, limited temperature sensitivity and/or increased sensitivity to body heating) - Persons who do not appear to be cognitively or cardiopulmonarily capable of taking short breaths lasting 9 seconds - Persons whose pregnancy has not been ruled out with certainty - In the subgroup consisting of persons without post-COVID syndrome any of the following symptoms: o Fatigue o Headache o Muscle weakness/muscle pain o Anxiety/depression o Memory/concentration disorders o Smell/taste disorders o Sleep disorders o Dizziness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study is the BOLD fMRI signal increase in response to short breath-hold periods, as well as the BOLD signal changes at resting state. The BOLD signal response will be evaluated globally and regionally. | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation of the signal change with the results of clinical examinations will be correlated. | — |
Countries
Germany
Contacts
Public ContactLeonie Zerweck
Universitätsklinikum Tübingen
Outcome results
None listed