Second- and third-trimester termination of pregnancy: physiological, neurobiological and psychological adaptation and long-term consequences

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00033060

Enrollment

102

Registered

2024-01-18

Start date

2025-03-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

P96.4 O04

Interventions

Group 1: Patients with a medical indication for TOP (termination of pregnancy) in the 2nd/3rd trimester are recruited and monitored until 24 weeks after the TOP. MRI measurements are carried out befor

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with 1st trimester TOP and patients with 2nd/3d trimester TOP

Exclusion criteria

Exclusion criteria: History of psychosis or manic episodes, alcohol or psychotropic substance dependence, insufficient knowledge of German, English or Russian. Exclusion criteria relating to the MRI examination (metal implants, pacemakers, epilepsy or claustrophobia, etc.)

Design outcomes

Primary

Measure	Time frame
Characterization of the physiological, neurobiological and psychological adaptation processes, especially within the first 6 months after the TOP.	—

Secondary

Measure	Time frame
Investigation and comparison of the different effects of TOP in the 1st trimester of pregnancy and TOP in the 2nd/3rd trimester	—

Countries

Germany

Contacts

Public ContactSusanne Nehls

Uniklinik RWTH Aachen

snehls@ukaachen.de+49 241 8037098

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026