Healthy participants
Conditions
Interventions
Group 1: low MoCA-real rTMS intervention (5 sessions of 20 minutes over 1 week)
Group 2: low MoCA-sham rTMS intervention (5 sessions of 20 minutes over 1 week)
Group 3: NA-real rTMS intervention (5 se
Sponsors
Universitätsmedizin Göttingen
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: Age between 55 and 85.
Exclusion criteria
Exclusion criteria: 1. Severe Cardiovascular diseases such as Heart Failure (EF < 45%), any Arrythmias (such as Atrial Fibrillation, Sick sinus syndrome or Bradycardias), Heart Valves Insufficiency or Stenosis; 2. History of Myocardial Infarction and/or Cardiac Arrest, CPR or Cardiovascular Surgery; 3. Heart Pacemaker or Defibrillator, or other Heart Devices; 4. Anticoagulation therapy related to cardiovascular disease; 5. Metal implants in the head area (e.g. clips after surgery of an intracerebral aneurysm, implantation of an artificial cochlea); 6. Evidence of a chronic disease or residuals (remnants) of a neurological disease (disease of the nervous system) in history; History of intracerebral ischemia (insufficient blood flow to the brain/stroke); Evidence of a history of epileptic seizures or stroke; multiple sclerosis; 6. Presence of a serious internal or neurological disease (e.g. untreated tumors, cancer, Parkinson's disease, multiple sclerosis); 7. Psychiatric diseases (schizophrenia, major depression); 8. Head trauma with a history of loss of consciousness; 9. Glaucoma, retinitis pigmentosa, macular degeneration in an advanced stadium; 10. Alcohol or drug addiction; 11. Operations within the last three months; 12. Participation in another clinical trial within the last 6 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive performance in cognitively impaired and normal aging subjects is improved on cognitive tasks after frontal-vagal rTMS intervention. Furthermore, their heart rate variability will increase by collecting EEG-ECG data after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neurocardiac-guided TMS (NCG-TMS) can optimize the stimulation site in cognitively impaired and normal aging subjects. 2. The combination of internal regulation (resonance frequency breathing) and external regulation (brain stimulation) is more effective in cognitive improvement than single external regulation. | — |
Countries
Germany
Contacts
Public ContactAndrea Antal
Universitätsmedizin Göttingen
Outcome results
None listed