Keratoconjunctivitis sicca
Conditions
Interventions
Group 1: Observational group:
In this study, clinical parameters for the assessment of dry eye and the inflammatory reaction of the ocular surface, which are routinely collected during the anterior se
Sponsors
Carl von Ossietzky Universität Oldenburg, Universitätsklinik für Augenheilkunde
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Dry eye requiring treatment: OSDI score = 13 and additionally 1. either non-invasive tear film break-up time (NIBUT) 5 corneal spots (Oxford scale = 1) + a low Schirmer I test of = 5 mm) Subclassification: Patients are classified as evaporative dry eye (EDE group) if they have a NIBUT of 5 mm. Patients are classified as hypovolaemic dry eye (ADDE group) if they have a low Schirmer I test of = 5 mm.
Exclusion criteria
Exclusion criteria: Patients who would not be able to attend the follow-up appointments due to other illnesses or who cannot give their consent to the study are excluded. Furthermore, corneal surgery, inflammatory eye diseases (e.g. uveitis), tumour diseases and treatment with anti-inflammatory and immunosuppressive medication in the last 3 months are exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the cornea using confocal in vivo microscopy (IVCM) and comparison with clinical parameters | — |
Countries
Germany
Contacts
Public ContactSonja Mertsch
Carl von Ossietzky Universität Oldenburg, Universitätsklinik für Augenheilkunde
Outcome results
None listed