chronic kidney disease atrial fibrillation coronary heart disease
Conditions
Interventions
Group 1: AF (atrial fibrillation)-study: patients on dialysis with atrial fibrillation
CAD (coronary artery disease)-study: patients on dialysis with coronary artery disease
This study consists of tw
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • Patients over 18 years old with chronic kidney insufficiency from stage IV according to KDIGO • known atrial fibrillation and/or coronary heart disease • Stable kidney retention parameters • consistent administration of anticoagulants/platelet aggregation inhibitors and no medication change for at least 1 week, or no anticoagulants/platelet aggregation inhibitors due to high bleeding risk.
Exclusion criteria
Exclusion criteria: • Pregnant • Patients with known coagulation disorders, liver insufficiency, or active cancer disease • Acute kidney failure in the current hospital stay • Severe thrombocytopenia ( 450,000/µl) • Noncompliance, lack of consistent medication intake
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AF-study: combined endpoint with bleeding and all-cause-death CAD-study: combined endpoint with MACE (apoplex, myocardial infarction, all-cause-death) | — |
Secondary
| Measure | Time frame |
|---|---|
| AF-study: coagulation parameters (anti-factor-Xa activity, PPT, INR), apoplex, myocadial infarction CAD-study: platelet function, bleeding | — |
Countries
Germany
Contacts
Public ContactTian Li
Universitätsklinikum Freiburg
Outcome results
None listed