Long-term performance and longevity of minimally invasive CAD/CAM versus conventional anterior veneer restorations: A randomised controlled trial over 5 years.

Long-term performance and longevity of minimally invasive CAD/CAM versus conventional anterior veneer restorations: A randomised controlled trial over 5 years. - Veneer RCT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032994

Enrollment

Registered

2025-05-22

Start date

2025-07-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Restorative treatment of missing tooth structure to restore chewing function, phonetics and aesthetics.

Interventions

Group 1: Control Group: Conventional veneer restorations Group 2: Study Group: CAD/CAM veneer restoration

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Patients = 18 years of age • Patients that reveal indication for a minimum of 2 and a maximum of 6 anterior veneer restorations

Exclusion criteria

Exclusion criteria: • Patients that reveal multiple missing teeth, poor oral hygiene, pronounced parafunctions or with allergies to any of the applied materials

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the prosthetic survival time (in months) until absolute failure of restorations within 5 years after placement. In addition, given sufficient non-censored data, survival will be calculated as Kaplan-Meier survival rate 5 years after placement of the restorations. Failure will be defined on an individual tooth level by clinical unacceptable conditions which will require a replacement of the entire restoration. These conditions are fracture of the all-ceramic restoration material, secondary caries, irreversible debonding, severe marginal discoloration and unacceptable degradation of surface structure and anatomic form. Survival of dental restorations will be assessed by use of FDI criteria.	—

Measure

Time frame

The primary endpoint is the prosthetic survival time (in months) until absolute failure of restorations within 5 years after placement. In addition, given sufficient non-censored data, survival will be calculated as Kaplan-Meier survival rate 5 years after placement of the restorations. Failure will be defined on an individual tooth level by clinical unacceptable conditions which will require a replacement of the entire restoration. These conditions are fracture of the all-ceramic restoration material, secondary caries, irreversible debonding, severe marginal discoloration and unacceptable degradation of surface structure and anatomic form. Survival of dental restorations will be assessed by use of FDI criteria.

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Secondary

Measure	Time frame
The secondary endpoints are the prosthetic success rate 5 years after placement of the restorations and patient centred satisfaction. Success will be defined on an individual tooth level. The calculation of the success rate uses the dichotomization of the data into sufficient (FDI criteria scores 1 - 3) and insufficient (FDI criteria scores 4 and 5). Failures such as fractures within the all-ceramic restoration will be documented by the replica/SEM technique for fractographic analysis. Patients’ oral health related quality of life will be assessed via visual analog scales (VASs; 0 = not satisfied, 10 = fully satisfied ), dentists will also provide ratings.	—

Measure

Time frame

The secondary endpoints are the prosthetic success rate 5 years after placement of the restorations and patient centred satisfaction. Success will be defined on an individual tooth level. The calculation of the success rate uses the dichotomization of the data into sufficient (FDI criteria scores 1 - 3) and insufficient (FDI criteria scores 4 and 5). Failures such as fractures within the all-ceramic restoration will be documented by the replica/SEM technique for fractographic analysis. Patients’ oral health related quality of life will be assessed via visual analog scales (VASs; 0 = not satisfied, 10 = fully satisfied ), dentists will also provide ratings.

—

Countries

Germany

Contacts

Public ContactPetra Gierthmühlen

Poliklinik für Zahnärztliche Prothetik - Universitätsklinikum Düsseldorf

Petra.Gierthmuehlen@med.uni-duesseldorf.de+49 211 81-18142

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026