Protection against exercise-induced muscle damage by 8 weeks of Omega-3 supplementation in older adults.

Protection against exercise-induced muscle damage by 8 weeks of Omega-3 supplementation in older adults. - PROTECT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032985

Enrollment

Registered

2024-01-30

Start date

2024-02-12

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Interventions

Group 1: Control, 5 mL 1x daily, Placebo containing sunflower-, olive- and citrusoil Group 2: Omega-3 Supplementation, 5 mL 1x daily, algae oil, (containing 609 mg eicosapentaenoic acid, 1158 mg docos

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: - Age: 65-85 - BMI between 22-30 kg/m²

Exclusion criteria

Exclusion criteria: - Active smokers - Athletes - Atrial fibrillation, known/past cardiac arrhythmias or heart attacks - Arterial hypertension (resting blood pressure > 140/90 mmHg) - Taking blood lipid-lowering drugs (statins), antiarrhythmics (such as flecainide, propafenone, amiodarone, dronedarone) and anticoagulant medications (such as Apixaban, Marcumar) - Food intolerances/allergies to seafood or algae - Taking dietary supplements containing polyunsaturated fatty acids, including omega-3 fatty acids - Diagnosed with diabetes mellitus - Presence of malignant neoplasms, HIV - self-reported serious diseases of the cardiovascular system such as arteriosclerosis or advanced heart disease (NYHA grade =2 (“New York Heart Association” classification)), acute respiratory diseases or severe chronic lung diseases (COPD; GOLD stage =2 (“Global Initiative for Chronic Obstructive Lung Disease” classification)) - self-reported severe liver, kidney or metabolic diseases, such as liver cirrhosis (Child Pugh Score =2) or renal insufficiency (stage =3)

Design outcomes

Primary

Measure	Time frame
Isometric force loss of the quadriceps following 100 repetitions leg extensions after eight weeks, determined from the quadriceps strength changes on examination days 3, 4 and 5.	—

Secondary

Measure	Time frame
Inflammation after 8 weeks in comparison to baseline, determination of IL-6 and CRP concentrations in the blood using ELISA	—

Countries

Germany

Contacts

Public ContactCatrin Herpich

German Institute of Human Nutrition Potsdam-Rehbrücke

Catrin.Herpich@dife.de+49 33200 882775

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026