Lesional and perilesional damage and recovery of the brain after acute ischemic stroke rated by combined 1H- and 31P-Spectroscopy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032960

Enrollment

Registered

2023-12-28

Start date

2025-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute ischemic stroke

Interventions

Group 1: Patients are examined in the subacute stage (1-3 days after an acute stroke) and in the chronic stage (8 weeks after an acute stroke) using MR spectroscopy. The spectroscopic measurements in

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Subacute ischemic stroke (maximum 1-3 days after acute event) - demarcated lesion in imaging (DWI, T2w) - Voluntary participation after being informed of the benefits and risks of the examination - Written consent of the subject

Exclusion criteria

Exclusion criteria: - Reduced general condition that does not allow for an examination duration of approximately 45 minutes - Pregnancy Implanted electronic devices that do not allow measurement within or in the presence of a magnetic field. This includes implanted pacemakers, neurostimulators, drug pumps, and cochlear implants. - Magnetizable metal objects within the body (e.g., shards, clips, or staples from surgeries before 1990, metal fragments in the body, such as those acquired from working in the metalworking industry) - claustrophobia

Design outcomes

Primary

Measure	Time frame
WHAT: This is an exploratory study aimed at analyzing the metabolic processes in damaged brain and surrounding tissue over time. Therefore, multiple spectroscopically measurable parameters are collected (1H spectroscopy: lactate, NAA, glutamine, glutamate, GABA, myoinositol, creatine, choline. 31P spectroscopy: ATP, phosphocreatine, inorganic phosphate, pH, choline, and ethanolamine-containing cell membrane metabolites). WHEN: 1-3 days and 8 weeks after acute ischemic stroke. HOW: MR spectroscopy.	—

Measure

Time frame

WHAT: This is an exploratory study aimed at analyzing the metabolic processes in damaged brain and surrounding tissue over time. Therefore, multiple spectroscopically measurable parameters are collected (1H spectroscopy: lactate, NAA, glutamine, glutamate, GABA, myoinositol, creatine, choline. 31P spectroscopy: ATP, phosphocreatine, inorganic phosphate, pH, choline, and ethanolamine-containing cell membrane metabolites). WHEN: 1-3 days and 8 weeks after acute ischemic stroke. HOW: MR spectroscopy.

—

Secondary

Measure	Time frame
WHAT: Clinical symptoms. WHEN: 1-3 days and 8 weeks after acute ischemic stroke. HOW: Physical examination with assessment of the NIHSS.	—

Countries

Germany

Contacts

Public ContactLeonhard Mann

Klinikum der Goethe-Universität Frankfurt

leonhard_mann@web.de+49-69-6301-5462

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026