M45
Conditions
Interventions
Group 1: axSpA abbreviation group with high-intensity endurance training (HIIT).
The supervised HIIT training on the cycle ergometer takes place three times a week for 12 weeks.
Group 2: axSpA contro
Sponsors
Rheumazentrum Ruhrgbiet
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Confirmed clinical diagnosis of axSpA - axSpA patients with stable bionaive medication - axSpA patients with stable TNFi (b-DMARD) Medication - age > 18 years - Eligibility for participation in performance diagnostics and in the high-intensity interval training on the cycle ergometer
Exclusion criteria
Exclusion criteria: - axSpA patients* with other b- or ts-DMARDs. Medication - Individuals with significant limitations in physical functioning due to a concomitant concomitant disease - Patients who are not scheduled for MRI as part of routine treatment no MRI examination is planned - Pregnant/breastfeeding women - Unstable CVD - Angina pectoris CCS class = I - Signs of heart failure - Acute hypertensive derangement or Inadequately controlled arterial hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of BME lesions in the spine and sacroiliac (calculated with the Berlin Score) which occurred in the last 3 months have occurred | — |
Secondary
| Measure | Time frame |
|---|---|
| - Amount of bone marrow edema (BME) lesions in the spine and sacroiliac joint (calculated with the Berlin Score) that have resolved in the last have resolved in the last 3 months - Amount of subjects who had no positive imaging during the 3 positive imaging (calculated with the Berlin Score) in the course of the 3 months - Change in disease activity (ASDAS) after 3 months of HIIT - Change in physical performance - Change in physical functioning (BASFI) after 3 months of HIIT - Change in the mSAQUASH/ or other arc for recording physical activity - Change in the number of pressure painful tendon insertions (enthesitis score SPARCC) - Change in ASAS-NSAIDs score over 3 months - Change in pain on the numeric Rating Scale (NRS) 0 - 10 over 3 months. - Change in ASAS health index, - Change in BASDAI, - Change in Patient Global, - Change in modified Squash Questionnaire, - Change in SF-36, - change in EQ-5D - Change in BASMI | — |
Countries
Germany
Contacts
Public ContactXenofon Baraliakos
Rheumazentrum Ruhrgbiet
Outcome results
None listed