Recalibration of audio-visual synchronicity and its impact on perception in children and adolescents with autism spectrum disorder

Recalibration of audio-visual synchronicity and its impact on perception in children and adolescents with autism spectrum disorder - Multisensory training in children and adolescents with autism spectrum disorder (MUTRAKiA)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032847

Enrollment

Registered

2024-01-25

Start date

2024-01-16

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F84.0 F84.1 F84.5

Interventions

Group 1: Audiovisual training to recalibrate the audiovisual synchronicity in children and adolescents with autism spectrum disorder (Simultaneity Judgement Task with Feedback, 1 session of approximat

Eligibility

Sex/Gender

All

Age

8 Years to 18 Years

Inclusion criteria

Inclusion criteria: - Presence or exclusion (in the control group) of ASD (also applies to first-degree relatives) - Fluent speech

Exclusion criteria

Exclusion criteria: - Known genetic or current neurological disease affecting the CNS - Use of psychoactive substances - Uncorrected visual impairment - Hearing impairment - Dyslexia

Design outcomes

Primary

Measure	Time frame
The primary outcome is the effect of the multisensory training on the temporal binding window. To determine the size of the temporal integration window, sigmoid curves are fitted for each individual, which represent the mean value of the synchrony judgment for each stimulus-onset asynchrony (SOA). For each SOA, the probability that the participant perceives the presented stimuli as synchronous is determined. The size of the temporal integration window is defined as the width of the distribution (in ms) at a 75% probability of perceiving the presented stimuli as synchronous. The multisensory training is considered successful when there is a significant reduction in the size of the temporal binding window after the training. The size of the temporal binding window is estimated directly before (T0) and after the multisensory training (T1), and 7 (T3) and 14 days (T4) after the multisensory training.	—

Measure

Time frame

The primary outcome is the effect of the multisensory training on the temporal binding window. To determine the size of the temporal integration window, sigmoid curves are fitted for each individual, which represent the mean value of the synchrony judgment for each stimulus-onset asynchrony (SOA). For each SOA, the probability that the participant perceives the presented stimuli as synchronous is determined. The size of the temporal integration window is defined as the width of the distribution (in ms) at a 75% probability of perceiving the presented stimuli as synchronous. The multisensory training is considered successful when there is a significant reduction in the size of the temporal binding window after the training. The size of the temporal binding window is estimated directly before (T0) and after the multisensory training (T1), and 7 (T3) and 14 days (T4) after the multisensory training.

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Secondary

Measure	Time frame
The secondary outcome is the dynamic change in the size of the temporal binding window at the level of individual trials, referred to as rapid recalibration of audiovisual integration. In addition, the improvement of performance in the Word Recognition Task (WRT), quantified by the percentage of correct answers, is an important secondary outcome. The secondary outcomes will also be analyzed at T0-T4 and compared between groups.	—

Measure

Time frame

The secondary outcome is the dynamic change in the size of the temporal binding window at the level of individual trials, referred to as rapid recalibration of audiovisual integration. In addition, the improvement of performance in the Word Recognition Task (WRT), quantified by the percentage of correct answers, is an important secondary outcome. The secondary outcomes will also be analyzed at T0-T4 and compared between groups.

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Countries

Germany

Contacts

Public ContactLabor für Kognitive Neuropsychiatrie

Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie der Medizinischen Hochschule Hannover

mupsy@mh-hannover.de+49 511 532-7363

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026