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Double sequential external defibrillation in refractory ventricular fibrillation - the DOSEVF2 trial, a prospective cluster randomised study

Double sequential external defibrillation in refractory ventricular fibrillation - the DOSEVF2 trial, a prospective cluster randomised study - DOSEVF2

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00032830
Enrollment
752
Registered
2024-07-16
Start date
2025-07-11
Completion date
Unknown
Last updated
2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I46.0

Interventions

Group 1: In the control group, standard treatment is carried out in accordance with the applicable ERC guidelines. This includes securing the airway, defibrillation and administering medication. In ad

Sponsors

Universitätsklinikum Heidelberg
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Out of hospital cardiac arrest VF or pVT or “shockable rhythm” determined by an AED Refractory VF/pVT defined as persistent VF/pVT after three defibrillations First dose of amiodarone (300mg) or lidocaine (100mg) according to current ERC guidelines

Exclusion criteria

Exclusion criteria: DNR/DNI Recurrent cardiac arrest with any-ROSC before 4th shock Stacked Defibrillation

Design outcomes

Primary

MeasureTime frame
Hierarchical testing (1)Successful termination of VF / pVT (2)Survival at 24 hours (3)Survival at 30 days with good neurological outcome (CPC 1-2)

Secondary

MeasureTime frame
CPC 1-2 or mRS =2 at hospital discharge ROSC at hospital admission Overall survival at hospital discharge Overall survival at day 30 Differences in survival between study phases within each cluster Any ROSC during prehospital phase Differences in Joules used Differences in impedance Differences in survival between study sites

Countries

Germany

Contacts

Public ContactStephan Katzenschlager

Universitätsklinikum Heidelberg

Stephan.Katzenschlager@med.uni-heidelberg.de+4962215639683

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026