Mechanisms of Implant Failure during Aseptic Loosening of Hip and Knee Endoprotheses (Cell biology of aseptic implant loss)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032796

Enrollment

200

Registered

2023-10-05

Start date

2022-02-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M16 M17

Interventions

Group 1: Intraoperative collection of specimen material during revision surgery of the hip (aseptic loosening). Group 2: Intraoperative collection of specimen material during primary implantation of a

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients with coxarthrosis who have a total hip arthroplasty implanted - Patients with gonarthrosis who are implanted with a total knee arthroplasty - Patients with revision surgery on the hip due to implant loosening - Patients with revision surgery on the knee due to implant loosening

Exclusion criteria

Exclusion criteria: - Detection of infections with hepatitis viruses, MRSA - Known depression - Heavy smokers - Patients with positive tumor history

Design outcomes

Primary

Measure	Time frame
The primary goal is to characterize cell populations and their molecular composition in the lo-cal and systemic tissue response ("host response") in the context of hip and knee implants.	—

Countries

Germany

Contacts

Public ContactYvonne Noll

Orthopädische Klinik der Medizinischen Hochschule Hannover im Diakovere Annastift

yvonne.noll@diakovere.de+49 511 5354 649

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026