Personalization of digital twin models using characteristic electrogram signatures to identify atrial fibrillation initiation sites as potential ablation target (AF-Twin)

Personalization of digital twin models using characteristic electrogram signatures to identify atrial fibrillation initiation sites as potential ablation target (AF-Twin) - AF-Twin

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032781

Enrollment

Registered

2024-01-26

Start date

2024-06-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I48.0 I48.1

Interventions

Group 1: single arm study, Redo-PVI patients with an indication for catheter ablation for atrial fibrillation (PVI = Pulmonary Vein Isolation)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - scheduled for electrophysiological redo procedure for ablation of atrial fibrillation - post ablation for atrial fibrillation (PVI) - age > 18 years - Study participants are willing and able to give their written consent to participate in the study and agree to participate in all follow-up examinations and evaluations.

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Complete high density 3D map of the left atrium in sinus rhythm (SR) and measurement of effective refractory period (ERP) at a minimum of 5 sites	—

Secondary

Measure	Time frame
- Number of identified Atrial Fibrillation Initiation Sites (AFIS) - Correlation of AFIS and Non-AFIS with ablation sites - Correlation of ablated AFIS and Non-AFIS with the clinical success after 6 and 12 month - Freedom from atrial fibrillation (Afib) after 6 and 12 month depending on AFIS and Non-AFIS sites - Freedom from atrial tachycardia (AT) after 6 and 12 month depending on AFIS and Non-AFIS sites	—

Measure

Time frame

- Number of identified Atrial Fibrillation Initiation Sites (AFIS) - Correlation of AFIS and Non-AFIS with ablation sites - Correlation of ablated AFIS and Non-AFIS with the clinical success after 6 and 12 month - Freedom from atrial fibrillation (Afib) after 6 and 12 month depending on AFIS and Non-AFIS sites - Freedom from atrial tachycardia (AT) after 6 and 12 month depending on AFIS and Non-AFIS sites

—

Countries

Germany

Contacts

Public ContactArmin Luik

Städtisches Klinikum Karslruhe

armin.luik@klinikum-karlsruhe.de+49 721 974 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026