Effect of Vitamin D receptor polymorphism on bone mineral density and metabolism in patients with systemic sclerosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00032768

Enrollment

100

Registered

2023-10-05

Start date

2013-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M34.0

Interventions

Group 1: Patients diagnosed with SSc with fulfillment of the ACR/EULAR classification criteria of 2013

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Systemic sclerosis meeting 2013 ACR/ EULAR classification criteria, informed consent for study participation

Exclusion criteria

Exclusion criteria: Secondary osteoporosis, glucocorticoid therapy

Design outcomes

Primary

Measure	Time frame
Statistical association between VDR gene polymorphisms (FokI or BsmI genotypes) and decreased BMD/osteoporosis measured by DXA	—

Secondary

Measure	Time frame
Statistical associations between laboratory values, including bone metabolism parameters, and VDR gene polymorphisms.	—

Countries

Germany

Contacts

Public ContactUwe Lange

Kerckhoff Klinik

u.lange@kerckhoff-klinik.de060329966102

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 6, 2026