Diabetes mellitus typ 1 with and without ketoacidose
Conditions
Interventions
Group 1: Children with newly diagnosed T1D without DKA
Cardiac biomarkers and cardiac function diagnostics (ECG, echocardiography) are used to look for cardiac function abnormalities in the context of
Sponsors
Kinder- und Jugendkrankenhaus AUF DER BULT
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: - Manifestation of type 1 diabetes - Age 0 - 17 years - Written consent from at least one parent/legal guardian
Exclusion criteria
Exclusion criteria: - Known heart defects such as hemodynamically relevant ventricular or atrial septal defect, transposition of the great arteries, aortic isthmus stenosis, tetralogy of Fallot, hypoplastic left heart syndrome, Ebstein anomaly, double aortic arch - Pre-existing heart failure - Known arterial hypertension - Known renal insufficiency - Chronic pulmonary diseases: severe bronchial asthma, cystic fibrosis, pulmonary hypertension - Cancers with a history of chemotherapy - Pregnancy (clinical indication)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of pathologically elevated cardiac biomarkers and their correlation with functional abnormalities in DKA | — |
Secondary
| Measure | Time frame |
|---|---|
| - Influence of the pH value on the increase in troponin I - Evaluation of the volume administered on NT-proBP elevation - Influence of the administered volume on echocardiographically proven contractility disorders - Evaluation of different troponin elevation between the sexes | — |
Countries
Germany
Contacts
Public ContactJantje Weiskorn
Kinder- und Jugendkrankenhaus AUF DER BULT
Outcome results
None listed