Characterisation of lymphocytes in pediatric patients with inborn disorders of the immune system

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00032712

Enrollment

Registered

2024-03-11

Start date

2021-04-15

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

D81 D82

Interventions

Group 1: Observational study: after initial diagnosis a blood sample of pediatric patients with inborn disorders of the immune system, in this case SCID patients, will be taken. A 13-colour flow cytom

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Inclusion criteria

Inclusion criteria: Diagnosis of immune defect written consent controls: patients with partial DiGeorge Syndrome

Exclusion criteria

Exclusion criteria: after hematopoetic stem cell transplantation after thymus transplantation acute infections Tumour Diseases, which impact the immune system (latent or persistent viral infections)

Design outcomes

Primary

Measure	Time frame
Phenotypic and transcriptional analyses of peripheral lymphocytes. Aim of this study is to understand how the cell count, frequencies, transcriptome, and phenotype of ILCs, NK cells, and T cells differ in these patients from reference values in healthy individuals.	—

Secondary

Measure	Time frame
Generation of a first hypothesis of the developmental relationship between lymphocytes in particular NK cells, T cells and ILCs	—

Countries

Germany

Contacts

Public ContactSabrina B. Bennstein

Institut für Transplantationsdiagnostik und Zelltherapeutika (ITZ), Heinrich-Heine Universität Düsseldorf

sabrinabianca.bennstein@med.uni-duesseldorf.de+492118116893

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026