Identification and characterization of antimicrobial antibodies in the serum of patients with periodontitis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00032671

Enrollment

200

Registered

2024-02-15

Start date

2024-02-21

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05

Interventions

Group 1: Participants who have been afflicted with periodontitis for several years and/or have an especially progressive form of the condition (Grade C). To establish a control group, approximately 10

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The following general criteria must be met for inclusion in the study: - Capacity to provide informed consent - Patients with periodontitis as well as individuals without a diagnosis of periodontitis, provided all other inclusion criteria are met, and no exclusion criteria apply. Additionally, the following criteria must be checked and satisfied immediately before blood collection: - Puncture site: Free from lesions or infections - Presence of a signed informed consent form for participation in the study

Exclusion criteria

Exclusion criteria: - Existing cytopenias (leukocytes 2 kg, diabetic metabolic state, pulmonary exacerbation, or loss of lung function (FEV1 > 10%) in the past 3 months - No fever

Design outcomes

Primary

Measure	Time frame
The identification of functional antibodies from the sera of periodontitis patients with a long-standing history and/or progressive form of periodontitis (Grade C) involves titration of blood sera against potent virulence factors of the key periodontal pathogen Porphyromonas gingivalis (PA strain), followed by the establishment of various immunological assays utilizing sera from patients with particularly high titers. Isolation of B cells from sera exhibiting particularly inhibitory antibodies, followed by subsequent antibody production. In vitro testing of the generated antibodies.	—

Measure

Time frame

The identification of functional antibodies from the sera of periodontitis patients with a long-standing history and/or progressive form of periodontitis (Grade C) involves titration of blood sera against potent virulence factors of the key periodontal pathogen Porphyromonas gingivalis (PA strain), followed by the establishment of various immunological assays utilizing sera from patients with particularly high titers. Isolation of B cells from sera exhibiting particularly inhibitory antibodies, followed by subsequent antibody production. In vitro testing of the generated antibodies.

—

Secondary

Measure	Time frame
New insights into the relationships between immunological processes and clinical parameters	—

Countries

Germany

Contacts

Public ContactGreta Barbe

Abteilung für zahnerhaltung & Parodontologie // Klinik für Zahn- Mund- und Kieferheilkunde

greta.barbe@uk-koeln.de+49 221 478-96743

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026