Q44.2
Conditions
Interventions
Group 1: Children with biliary atresia from 1 year onwards, not transplanted and not actively listed for liver transplantation
dietary intervention with prebiotics for the duration of 8 weeks: Children receive corn starch 5 g ( 5 years) in addition to their regular diet. Stool samples will be obtained prior to study start and
dietary intervention with prebiotics for the duration of 8 weeks: Children receive Lactobacillus GG 2x 10exp10 CFU daily in addition to their regular diet. Stool samples will be obtained prior to stud
Sponsors
Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
2 Months to 18 Years
Inclusion criteria
Inclusion criteria: biliary atresia
Exclusion criteria
Exclusion criteria: history of liver transplantation or being actively waitlisted for liver transplantation
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| beta diversity of gut microbiota from before to after nutritional intervention, change in fecal and serum bile acids, change in plasma endotoxin levels | — |
Primary
| Measure | Time frame |
|---|---|
| alpha diversity (Chao Index) based on 16s rRNA analysis of fecal microbiota composition before and after nutritional intervention. Primary endpoint is the change in alpha diversity as measured by the Chao Index from before to after intervention. Chao index will be calculated from 16srRNA based amplification of bacterial DNA in fecal samples. | — |
Countries
Germany
Contacts
Public ContactImeke Goldschmidt
Medizinische Hochschule Hannover
Outcome results
None listed