Parkinson's Disease, Essential Tremor
Conditions
Interventions
Group 1: Clinical assessment of deep brain stimulation effects with a stimulation frequency of 130 Hz
Group 2: Clinical assessment of deep brain stimulation effects with a stimulation frequency of 18
Sponsors
Universität zu Köln, Zentrum für Klinische Studien Köln
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Uni- or bilateral implantation of DBS leads in the subthalamic nucleus (PD) or the ventral intermedius nucleus of the thalamus and the posterior subthalamic area (ET) at least 3 months prior to study inclusion and confirmed diagnosis of Parkinson's Disease or Essential Tremor. Patients with Parkinson’s Disease must have a relevant tremor burden defined as = 2 of 4 points of the MDS-UPDRS item 3.17 (rest tremor) without medication, patients with Essential Tremor =2 of 4 points of item 5/6 of the Fahn Tolosa Marin Tremor Rating Scale (postural or intention tremor). Patients must be able to consent to participate at the study and to give written informed consent prior to study inclusion.
Exclusion criteria
Exclusion criteria: Non-fulfillment of all inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in tremor suppression, assessed by accelerometry, with energy-equivalent stimulation using two different stimulation frequencies (130 Hz vs 185 Hz) | — |
Secondary
| Measure | Time frame |
|---|---|
| -Amplitude-equivalent effects of the different frequencies on tremor - effects on therapeutic window - for PD, effects on rigidity and bradykinesia | — |
Countries
Germany
Contacts
Public ContactChristina Hennen
Universitätsklinikum Köln, Klinik und Poliklinik für Neurologie
Outcome results
None listed