Heathy volunteers
Conditions
Interventions
Group 1: The general procedure of the behavioral experiment consists of an acquisition training, extinction training, and reinstatement phase of a classical conditioning paradigm. We will combine geom
Sponsors
Universitätsklinikum Essen (AöR)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - normal or corrected-to-normal vision with contact lenses - right-handedness
Exclusion criteria
Exclusion criteria: No fluency in German, BMI 30, chronic pain, severe diseases, or mental disorders, skin diseases, or skin damage, pregnancy or nursing, anisocoria, contraindication to MRI scans, allergic responses to cayenne pepper, previous participation in a fear conditioning study, and participation in any study investigating drug effects within the last three months, acute infection, pain at the study dates, engagement in professional sports at the study dates, consumption of psychoactive substances within 3h, or acute pain medication within 24 h before participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of expectancy ratings of CS-US-associations over the acquisition training, extinction training, and reinstatement test using a visual analogue scale with the anchors most probably cooling (-100), no change (0) and most probably heating (100). | — |
Secondary
| Measure | Time frame |
|---|---|
| Contingency ratings of CS-US coupling after each acquisition and extinction training, and reinstatement test, CS valence ratings before and after each phase, pain intensity and (un)pleasantness ratings of the US (temperature stimuli), electrodermal activity (skin conductance response) to CS and US, pupillometry to CS and US, resting state neural connectivity (rsfMRI). | — |
Countries
Germany
Contacts
Public ContactKatharina Schmidt
Universitätsklinikum Essen
Outcome results
None listed