K02 K05
Conditions
Interventions
Group 1: dental patients: Oral mucosal swab and saliva sample, dental status and periodontal measurement.
Patients with tumor diseases in the head and neck area: blood sampling, oral mucosa swab, sali
Sponsors
Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Dental patients or patients with a tumorous disease of the oral cavity or other tumorous diseases of the facial region.
Exclusion criteria
Exclusion criteria: - Genetic structural disorders of the tooth structure (e.g. amelogenesis imperfecta) - Lack of capacity to consent - Other reasons which, in the opinion of the treating or study-including physician, make participation in this study inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caries expression as a function of the AQP5 A(-1364)C promoter polymorphism at the time of study inclusion | — |
Secondary
| Measure | Time frame |
|---|---|
| - Periodontitis expression as a function of the AQP5 A(-1364)C promoter- polymorphism at the time of study inclusion - Prevalence of caries as a function of AQP5 A(-1364)C promoter polymorphism at the time of study inclusion - Prevalence of periodontitis as a function of AQP5 A(-1364)C promoter- polymorphism at the time of study inclusion - Prevalence of caries as a function of other polymorphisms of appropriate candidate genes at the time of study inclusion - Prevalence of periodontitis in dependence of other polymorphisms of suitable candidate genes at time of study inclusion - caries prevalence in dependence of other polymorphisms of appropriate candidate genes at the time of study inclusion - Periodontitis expression in dependence of other polymorphisms of suitable candidate genes at the time of study inclusion - Correlation of patient risk factors (e.g., previous diseases) with the prevalence of caries - Correlation of patient risk factors (e.g., preexisting conditions) with the prevalence of periodontitis For tumor patients, additionally: o correlation of tumor spread with the prevalence of caries o Correlation of tumor spread with the prevalence of periodontitis o Correlation of the tumor treatment modality (e.g., radiotherapy) with the prevalence of caries o Correlation of tumor treatment modality (e.g., radiotherapy) with the prevalence of periodontitis | — |
Countries
Germany
Contacts
Public ContactDaria Pakosch-Nowak
Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH
Outcome results
None listed