Individual Determinants of Antidepressant Response- a longitudinal study

Individual Determinants of Antidepressant Response- a longitudinal study - IDeA-L

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00032410

Enrollment

500

Registered

2025-06-04

Start date

2022-01-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32.2

Interventions

Group 1: Patients with severe depression and indication of treatment with antidepressants will be observed (clinical data, biomaterial, neuroimaging, electrophysiology) in a longitudinal course withou

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Moderate to severe unipolar depression < 60 years at first episode stationary or ambulatory treatment in the clinic indication for an antidepressive medication fluent german MRI-suitable

Exclusion criteria

Exclusion criteria: Indication for an ECT, Ketamin or sleep-deprivation therapy DSM-5 diagnose of dementia, schizophrenia, schizo- or bipolare depressive disorder current pregnancy traumatic brain injury in medical history severe internistic or neurological underlying disease

Design outcomes

Primary

Measure	Time frame
Identifying biomarkers associated with antidepressant treatment response	—

Secondary

Measure	Time frame
Finding biomarkers that differentiate between patients with unipolar depression based on their response to treatment	—

Countries

Germany

Contacts

Public ContactJan Engelmann

Klinik für Psychiatrie & Psychotherapie, Universitätsmedizin Mainz

jan.engelmann@unimedizin-mainz.de0049 6131-172920

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026