F32 F33
Conditions
Interventions
Group 1: Healthy subjects (N= 40) undergo a baseline examination (with measurement of attention control) and a behavioural experiment on expectation processes (two experiment days).
Baseline: declara
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: clinical group: - signed declaration of consent - treatment-requiring psychiatric disease with depressive syndrome healthy control group: - signed declaration of consent - MRI-compatible
Exclusion criteria
Exclusion criteria: clinical group: - neurological disease - psychotic disorder - bipolar disorder in manic phase - Dependency disease healthy control group: - History of psychiatric or neurological disease - current intake of effective central nervous drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Attention control: measured via singleton task at baseline day 2. mood-change (captured via VAS [time frame: baseline, before and after expectation induction during the experimental days] 3. Behavioral results in an emotion classification task (arm 1 and 3) or emotion interference task (arm 1 and 2) on both experimental days | — |
Secondary
| Measure | Time frame |
|---|---|
| applies for all Arms: 1. Expectation of the treatment with the nasal spray on the experimental days recorded by means of GEEE [time frame: after induction of expectation on the experimental days] 2. Experience through the treatment with the nasal spray on the experimental days recorded by means of GEEE [time frame: at the end of each experimental day] applies only for arm 3: 3. Severity of depressive symptoms (assessed by BDI-II and MADRS [time frame: baseline) 4. Previous experience with antidepressants and psychotherapy recorded by structured interview/GEEE [time frame: baseline] | — |
Countries
Germany
Contacts
Public ContactLeonie Schmidt
Universtiätsklinikum Hamburg-Eppendorf
Outcome results
None listed