G91.2
Conditions
Interventions
Group 1: Patients with normal pressure hydrocephalus (NPH) and spontaneous intracranial hypotension (SIH)
Sponsors
Klinik für Neurochirurgie - Uniklinik Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Suspected diagnosis of a cerebrospinal fluid circulation disorder Age > 18 years Presence of imaging of the neurocranium Clinical indication for the performance of a CSF infusion test Written consent
Exclusion criteria
Exclusion criteria: Intracranial tumour/malformation or tumour/malformation on the head (with the exception of malformations associated with the CSF circulation disorders mentioned above). - Contraindication to a lumbar infusion test - Non-removable external foreign bodies or large tattoos on head and neck - Pregnancy or breastfeeding - Patch allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| craniospinal compliance resp. Electrical capacity of the head Non-invasively measured blood pressure Respiratory and cardiac activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnosed aetiology of hydrocephalus, clinical parameters of gait disturbances, spatial impairment, cognitive abilities, urinary incontinence, pain caused by headaches, visual acuity, parameters of the computerised lumbar infusion test (baseline CSF pressure, pressure-volume index, pulse amplitude), documented intracranial pressures, cell count and total protein in the CSF, diameter of the sonographic optic nerve sheath (ONSD), radiological findings. The following additional variables will be collected: Age and gender of the study participants, BMI, height, presence of comorbidities using the Charlson Comorbidity Index (CCI). previous cranial operations, presence of cranial implants. | — |
Countries
Germany
Contacts
Public ContactMukesch Johannes Shah
Klinik für Neurochirurgie
Outcome results
None listed