Effect of mild to moderate blood loss on echocardiographic function parameters in healthy volunteers during normal whole blood donation: a prospective observational study

Effect of mild to moderate blood loss on echocardiographic function parameters in healthy volunteers during normal whole blood donation: a prospective observational study - REFILL

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00032297

Enrollment

Registered

2023-11-24

Start date

2023-12-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E86

Interventions

Group 1: Male whole blood donators

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: planed blood donation

Exclusion criteria

Exclusion criteria: cardiac/vasoactive/volume-active medication cardiac, pulmonary, hepatic, renal, metabolic or vascular disease Acute or chronic infections Exclusion criteria for blood donation

Design outcomes

Primary

Measure	Time frame
Reduction of LV-GLS in TTE after approximately 500ml whole blood donation.	—

Secondary

Measure	Time frame
Reduction of LV-GLS in TTE 1 hour after approximately 500ml whole blood donation	—

Countries

Germany

Contacts

Public ContactChristian Berger

Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin

christian.berger@charite.de+49 30 450 551522

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026