Study A: Effects of mechanical and metabolic stress on the Extent of BFR exercise-induced skeletal muscle damage: A Double-Blind Study.

Study A: Effects of mechanical and metabolic stress on the Extent of BFR exercise-induced skeletal muscle damage: A Double-Blind Study. - BFRA

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00032247

Enrollment

Registered

2023-07-12

Start date

2023-07-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influence of occlusion pressure during BFR training on muscle soreness.

Interventions

Group 1: - Group A1 is cuffed without significant inflation (up to 10 mmHg) (No Pressure, NP). - 18-35 years - Active in sports (at least 2 training sessions per week). On the day of the intervention

NIRS), rate of perceived exertion (RPE/BORG), and oxygen uptake (spirometry) are measured. At time intervals of 1, 3, 7, and 10 minutes after the intervention, subjects will then have their lactate co

Eligibility

Sex/Gender

All

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: - 18-35 years - Active in sports (at least 2 training sessions per week)

Exclusion criteria

Exclusion criteria: - Age 35 years - Injuries or acute or chronic illnesses - Taking medication - Individuals with previous damage to the venous system (e.g., varicose veins, vascular surgical surgery, extremities with dialysis access) - high blood pressure - Circulatory and coagulation disorders (e.g. condition after transient ischemic attack, stroke, angina pectoris, myocardial infarction, peripheral occlusive diseases)

Design outcomes

Primary

Measure	Time frame
The main objective of the study is to compare the muscular damage between the groups. To quantify this, a) the creatine kinase and myoglobin levels in capillary blood will be determined, b) the maximum extension and contraction time of the m. rectus femoris and m. vastus lateralis via tensiomyography, c) the changes in muscular stiffness via shear wave velocity by elastography of the m. rectus femoris and m. vastus lateralis, d) the change in peak torque at the isokinetic knee extensor, e) tissue temperature via thermography, and f) subjective pain perception (visual analog scale) and measured via ultrasound the muscle thickness of the m. rectus femoris and m. vastus lateralis. These parameters are measured before the intervention and 1, 24, 48, and 72 hours after the intervention. These damage markers will be used to test the hypothesis of whether mechanical and metabolic stress add up such that, although mechanical stress decreases with increasing cuff pressure, the parallel increase in metabolic stress causes the induced microtraumatization of muscle to be equal in magnitude. The results of this study will help to better assess the risk for BFR training-induced microtraumatization of the musculature.	—

Measure

Time frame

The main objective of the study is to compare the muscular damage between the groups. To quantify this, a) the creatine kinase and myoglobin levels in capillary blood will be determined, b) the maximum extension and contraction time of the m. rectus femoris and m. vastus lateralis via tensiomyography, c) the changes in muscular stiffness via shear wave velocity by elastography of the m. rectus femoris and m. vastus lateralis, d) the change in peak torque at the isokinetic knee extensor, e) tissue temperature via thermography, and f) subjective pain perception (visual analog scale) and measured via ultrasound the muscle thickness of the m. rectus femoris and m. vastus lateralis. These parameters are measured before the intervention and 1, 24, 48, and 72 hours after the intervention. These damage markers will be used to test the hypothesis of whether mechanical and metabolic stress add up such that, although mechanical stress decreases with increasing cuff pressure, the parallel increase in metabolic stress causes the induced microtraumatization of muscle to be equal in magnitude. The results of this study will help to better assess the risk for BFR training-induced microtraumatization of the musculature.

—

Secondary

Measure	Time frame
During exercise, muscle oxygen saturation will be measured via near-field infrared spectroscopy, rate of perceived exertion (RPE/BORG), and oxygen uptake via spirometry. At time intervals of 1, 3, 7, and 10 minutes after the intervention, lactate concentration and tissue temperature will also be recorded from the subjects. The results will be used to evaluate local and global fatigue and exertion in dependence on occlusion pressure during BFR training.	—

Measure

Time frame

During exercise, muscle oxygen saturation will be measured via near-field infrared spectroscopy, rate of perceived exertion (RPE/BORG), and oxygen uptake via spirometry. At time intervals of 1, 3, 7, and 10 minutes after the intervention, lactate concentration and tissue temperature will also be recorded from the subjects. The results will be used to evaluate local and global fatigue and exertion in dependence on occlusion pressure during BFR training.

—

Countries

Germany

Contacts

Public ContactKevin Happ

Goethe Universität Frankfurt, Institut für Sportwissenschaften

happ@sport.uni-frankfurt.de+49 69 798 244 85

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026