Major Depressive Disorder MDD (DSM-5) / rezidivierende depressive Störung, gegenwärtig mittelgradig bis schwer (ICD-10: F32.1-3 & F33.1-3) and/or Persistend Depressive Disorder (PDD
Conditions
Interventions
Group 1: 1000 depressed patients during an inpatient stay of 7 weeks
- All patients receive a diagnostic interview (Mini-DIPS), external assessment of depressive symptomatology (HDRS-24, MADRS, HAMA),
Sponsors
Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: MDD: F32.1-3, F33.1-3 first or recurrent depressive episode (confirmed by MINI-DIPS confirmed) and/or PDD: F34.1 - Symptom severity: Moderate to severe (MADRS = 20). - First depressive episode before 50 years of age - Signed informed consent form - Capacity to consent
Exclusion criteria
Exclusion criteria: Acute Suicidality Placement according to state law (e.g. §16/17 Nds. PsychKG) The following diagnoses in the life course: Dementia, schizophrenia, schizoaffective disorder, bipolar disorder, substance dependence with currently necessary detoxification Concurrent participation in other clinical trials that are not being conducted within the framework of the P4D project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| remission after 7 weeks of treatment (MADRS = 7 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. recording of psychometric changes in the clinical course of treatment 2. frequency of other concomitant treatments (e.g., additional psychotherapeutic treatment) 3. treatment/study dropout rates 4. expectations and attitudes of patients and practicing physicians towards treatment with antidepressants and the use of biomarkers to guide therapy (subproject Stiftung Deutsche Depressionshilfe and Suicide Prevention) 5. patient:in-treatment:in relationship | — |
Countries
Germany
Contacts
Public ContactHelge Frieling
Medizinische Hochschule Hannover
Outcome results
None listed