C07 C08.0 C08.1 C08.9
Conditions
Interventions
Group 1: male and female patients with ACC of different stages (primary, recurrent and metastatic)
If available, clinical data include the date of initial diagnosis, age, TNM classification, resection status, the presence of perineural invasion, histological growth pattern, therapy performed, occur
Sponsors
Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: As part of the planned study, patients with ACC in the head and neck area who are undergoing therapy at Heidelberg University Hospital are to be included after the study protocol has been checked and the ethics committee has given its approval. Patients with initial diagnosis or recurrence are included. In addition, patients with a benign disease of the salivary glands are to be included as a control group. These are initially selected at random and an adjustment in the final evaluation is intended to ensure comparability of both groups (benign vs. malignant).
Exclusion criteria
Exclusion criteria: Pre-existing mental illnesses, minors, patients who are not fully legally capable of giving consent, patients whose consent to the use of samples or data for an experimental study has been revoked.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Preclinical testing and establishment of various endoradiotherapies and schemes for the ACC | — |
Secondary
| Measure | Time frame |
|---|---|
| Ex vivo analysis of a molecular signature/biomarker for radioresistance, analysis of immune phenotypes, establishment of the purification of CTCs and their analysis of therapy response and resistance signatures | — |
Countries
Germany
Contacts
Public ContactJochen Heß
Experimentelle und Translationale Kopf-Hals-Onkologie, Hals-Nasen-Ohrenklinik Universitätsklinikum Heidelberg
Outcome results
None listed