pupillary light relfex
Conditions
Interventions
Group 1: total n = 30 participants
15 participants: method I - method II
In method I, 18 measurements of the pupillary light reflex (light stimulus at 0.1 lux) are performed: measurements 1-6 are adaptation measurements, measurements
Sponsors
Uniklinik RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 28 Years
Inclusion criteria
Inclusion criteria: written consent
Exclusion criteria
Exclusion criteria: - Subjects with epilepsy, peripheral nerve disorders or other neurological disorders (e.g. migraine, apoplexy, cerebral hemorrhage, neurodegenerative disorders); - Subjects with severe eye diseases (e.g. glaucoma, retinal detachment, pupillary motor disorders); - Subjects with mental diseases; - Subjects with metabolic diseases (e.g. diabetes mellitus); - Subjects taking medications that affect pupillary motor function, sympathetic or parasympathetic nervous system; - Subjects taking medications that influence the ability to react and concentrate (e.g. painkillers from level II according to WHO); - drug and/or alcohol abuse; - Visible head injuries or diseases in the area of the head; - Artificial eye lenses or the absence of an eye lens; - Pregnant, breastfeeding; - Skin diseases or sensitivity disorders of the feet; - Polyneuropathy; - Severe peripheral arterial occlusive disease; - Raynaud's syndrome; - Subjects with syncope;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amplitude of the pupillary light reflex in method I is expected to be significantly reduced in the exposures to ice water (pain) compared to the baseline measurement (no pain). With measurement method II, this effect is expected to disappear. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ice water exposure should result in moderate pain as measured by an NRS (numeric rating scale). | — |
Countries
Germany
Contacts
Public ContactMichael Kursawe
Uniklinik RWTH Aachen
Outcome results
None listed