Malignant neoplasm of the oral cavity, oropharynx, hypopharynx, larynx C14.8 C10.8 C32.8 C13.8
Conditions
Interventions
Group 1: patients with Head neck cancer
Sponsors
Universitätsklinikum Jena, Klinik für Hals-, Nasen- und Ohrenheilkunde
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients - with head and neck tumours - Men and women who come to the scene for the clarification of symptoms with suspicion for malignancy in the head and neck area in the otolaryngology clinic, - Primary tumors and recurrent tumors - HPV-independent (HPV+ and HPV-) - Age = 18 years Controls: - Patients without head and neck cancer who have undergone surgery tissue is obtained from the oropharynx, e.g. with recurrent Tonsillitis who present for tonsillectomy
Exclusion criteria
Exclusion criteria: - Salivary gland malignancies -Lack of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the sensitivity and specificity of selected biomarkers for the detection of head and neck tumors using tissue and non-invasive samples (smear and saliva) of the primary tumor using probe-based multiplex assay. Examination of tissue and saliva samples of recurrences and determination the sensitivity and specificity of the biomarkers. Analysis of the biomarkers in saliva samples from the follow-up in order to be able to follow an early detection of the recurrences by the markers. | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigation of sensitivity and specificity of tumor markers in the blood: Analysis of the compliance rate of the detected markers between Tissue and saliva samples in the primary tumor as well as recurrences that occur. Determination of sensitivity and specificity for individual marker regions and their combinations for the detection of head and neck tumors: Positivity rates of biomarkers in subgroups | — |
Countries
China, Germany
Outcome results
None listed