The study is transdiagnostic and thus includes a wide variety of Axis I and Axis II disorders according to ICD-10. Excluded are developmental disorders, intelligence disorders and neurodegenerative disorders.
Conditions
Interventions
Group 1: Patients with mental disorders
Included are 170 participants between 18 and 60 years with Axis I or Axis II disorders, excluding neurodegenerative- developmental- or intelligence disorder. P
Sponsors
Universitätsklinikum Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Understanding of the study information Voluntary signing of the informed consent form Age between 18 and 60 years For patients: - Axis I or II disorder - inpatient treatment in the Department of Psychiatry, Psychotherapy and Psychosomatics or outpatient treatment in the Polyclinic, Institute Outpatient Clinic and the Center for Mental Health for Students
Exclusion criteria
Exclusion criteria: Pregnancy chronic or acute physical illness acute suicidality inability to comply with the study protocol limited or completely suspended legal capacity court order for accommodation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of anger and aggressive reactions between participants and patients and developing subgroups based on that Therefore the Technical Provocation Paradigm and the modified Taylor Aggression Paradigm is used. In addition biological marker (respiration, pulse), hormonal marker (testosterone, estrogen, progesterone and cortisol), volatile organic substances and brain activity and connectivity are measured. Also important are behavioral measurements via Joystick movement and money deduction in the paradigm. Paradigms in the scanner - Taylor Aggression Paradigm - Technical Provocation Paradigm Measurements: - Brain activity and connectivity via fMRI (3T Siemens) - Endocrine Marker via saliva sample (passive drool method) - Molecules in breath via Proton-Transfer-Mass-Spectrometer - Subjective Evaluation via multiple questionnaires The measurements take place the same day and are directly linked to each other. The measurement starts with a saliva and a breath sample collection. Participants then work on the two provocation paradigms in the scanner for approximately 60 to 90 minutes and provide a saliva and breath sample again. The final task in the scanner is the Voodoo Doll Task, which takes approximately 20 minutes. Before the questionnaires are completed, the last saliva sample is taken. Over a period of four weeks (starting the day after the examination), participants then complete an approximately 5-minute questionnaire online three times a day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of aggression, impulsivity, traumatic experiences, daily anger plus testing of anger induction via Voodoo Doll Task - Voodoo Doll Task in the scanner - Affective Style Questionnaire (ASQ) - Aggression Questionnaire (BPAQ) - Selfishness Questionnaire (SQ) - Barratt Impulsiveness Scale (BIS-15) - Becks Depression Inventory II (BDI-II) - Childhood Trauma Questionnaire (CTQ) - Bermond-Vorst Alexithymia Questionnaire (BVAQ) - Aggression-ES-A | — |
Countries
Germany
Contacts
Public ContactLaura Dukek
Universitätsklinikum Aachen
Outcome results
None listed